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Article

Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes.

Biomolecules - 2 Jan 2024

Al-Attar Rasha, Jargstorf Joseph, Romagnuolo Rocco, Jouni Mariam, Alibhai Faisal J, Lampe Paul D, Solan Joell L, Laflamme Michael A

Abstract excerpt

The transplantation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has shown promise in preclinical models of myocardial infarction, but graft myocardium exhibits incomplete host-graft electromechanical integration and a propensity for pro-arrhythmic behavior. Perhaps contributing to this situation, hPSC-CM grafts show low expression of connexin 43 (Cx43), the major gap junction (GJ) protein, in...

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Identifiers

PMID: 38254663
DOI: 10.3390/biom14010061
PMCID: PMC10813327

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