Article
Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: evidence of a subpopulation of protective anti-pneumococcal B1a cells.
Immunology - 1 Jan 2016
Yamamoto Natsuo, Kerfoot Steven M, Hutchinson Andrew T, Dela Cruz Charles S, Nakazawa Naomi, Szczepanik Marian, Majewska-Szczepanik Monika, Nazimek Katarzyna, Ohana Noboru, Bryniarski Krzysztof, Mori Tsutomu, Muramatsu Masamichi, Kanemitsu Keiji, Askenase Philip W
Abstract excerpt
We describe a protective early acquired immune response to pneumococcal pneumonia that is mediated by a subset of B1a cells. Mice deficient in B1 cells (xid), or activation-induced cytidine deaminase (AID(-/-) ), or invariant natural killer T (iNKT) cells (Jα18(-/-) ), or interleukin-13 (IL-13(-/-) ) had impaired early clearance of pneumococci in the lung, compared with wild-type mice. In contrast, AID(-/-) mice...
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