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Article

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.

Nature communications - 9 Aug 2018

Stark Anne-Katrien, Chandra Anita, Chakraborty Krishnendu, Alam Rafeah, Carbonaro Valentina, Clark Jonathan, Sriskantharajah Srividya, Bradley Glyn, Richter Alex G, Banham-Hall Edward, Clatworthy Menna R, Nejentsev Sergey, Hamblin J Nicole, Hessel Edith M, Condliffe Alison M, Okkenhaug Klaus

Abstract excerpt

Streptococcus pneumoniae is a major cause of pneumonia and a leading cause of death world-wide. Antibody-mediated immune responses can confer protection against repeated exposure to S. pneumoniae, yet vaccines offer only partial protection. Patients with Activated PI3Kδ Syndrome (APDS) are highly susceptible to S. pneumoniae. We generated a conditional knock-in mouse model of this disease and identify a...

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Share to Antigens, CD19
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30093657
DOI: 10.1038/s41467-018-05674-8
PMCID: PMC6085315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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