Article
Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2011
Meyers Greta, Ng Yen-Shing, Bannock Jason M, Lavoie Aubert, Walter Jolan E, Notarangelo Luigi D, Kilic Sara S, Aksu Guzide, Debré Marianne, Rieux-Laucat Frédéric, Conley Mary Ellen, Cunningham-Rundles Charlotte, Durandy Anne, Meffre Eric
Abstract excerpt
Impaired immune functions leading to primary immunodeficiencies often correlate with paradoxical autoimmune complications; patients with hyper-IgM syndromes who are deficient in activation-induced cytidine deaminase (AID), which is required for class-switch recombination and somatic hypermutation, are prone to develop autoimmune diseases. To investigate the impact of AID-deficiency on early B-cell tolerance...
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