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Article

Interleukin-1 promotes coagulation, which is necessary for protective immunity in the lung against Streptococcus pneumoniae infection.

The Journal of infectious diseases - 1 Jan 2013

Yang Hyungjun, Ko Hyun-Jeong, Yang Jin-Young, Kim Jae-Jin, Seo Sang-Uk, Park Seung Gu, Choi Sun Shim, Seong Je Kyung, Kweon Mi-Na

Abstract excerpt

Interleukin (IL)-1 is a well-known cytokine for the initiation of innate immunity in bacterial infection. However, the underlying mechanism of IL-1 on the respiratory infection is not fully elucidated. We studied how IL-1 contributes to the host defense against Streptococcus pneumoniae. IL-1R(-/-) mice showed high mortality, local cytokine storm, and substantial infiltrates in the lower respiratory tract after...

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Identifiers

PMID: 23100560
DOI: 10.1093/infdis/jis651

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