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Article

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2014

Yammani Rama D, Leyva Marcela A, Jennings Ryan N, Haas Karen M

Abstract excerpt

Reductions in C4 levels may predispose individuals to infection with encapsulated bacteria as well as autoimmunity. In this study, we examined the role C4 has in protection against Streptococcus pneumoniae-induced autoimmunity. Mild respiratory infection with serotype 19F pneumococci selectively induced systemic anti-dsDNA IgA production in naive C4(-/-) mice, but not in C3(-/-) or wild-type mice. Systemic...

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Topics

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Share to Antibody Formation
Share to Complement C4
Share to Cross Reactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin A

Share to Lipopeptides

Share to Phosphatidylcholines

Share to Polysaccharides, Bacterial

Share to Toll-Like Receptor 2

Source

Open in PubMed Open full text

Identifiers

PMID: 25339671
DOI: 10.4049/jimmunol.1401462
PMCID: PMC4373073

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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