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PI3Kδ hyper-activation promotes the development of B cells that exacerbate <i>Streptococcus pneumoniae</i> infection in an antibody-independent manner

2018-03-18

Abstract excerpt

Streptococcus pneumoniae is a major cause of pneumonia and a leading cause of death world-wide. Antibody-mediated immune responses can offer protection against repeated exposure to S. pneumoniae , yet vaccines only offer partial protection. Patients with Activated PI3Kδ Syndrome (APDS) are highly susceptible to S. pneumoniae . We generated a conditional knockin mouse model of this disease and identified a CD19...

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Identifiers and source

Literature Corpus work
4652a065-aa6a-50c6-b324-27cf20447b20
DOI
10.1101/280651
Open publication

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PI3Kδ hyper-activation promotes the development of B cells that exacerbate <i>Streptococcus pneumoniae</i> infection in an antibody-independent mannerDOI 10.1101/280651
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