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Biosynthesis of Tetrahydroisoquinoline Antibiotics

15 Oct 2015

Abstract excerpt

The tetrahydroisoquinoline (THIQ) alkaloids are naturally occurring antibiotics isolated from a variety of microorganisms and marine invertebrates. This family of natural products exhibit broad spectrum antimicrobial and strong antitumor activities, and the potency of clinical application has been validated by the marketing of ecteinascidin 743 (ET-743) as anticancer drug. In the past 20 years, the biosynthetic...

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PMID: 26456466
DOI: 10.2174/1568026616666151012112329

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