Article
Mutasynthesis of pyrrole spiroketal compound using calcimycin 3-hydroxy anthranilic acid biosynthetic mutant.
Applied microbiology and biotechnology - 1 Sept 2013
Gou Lixia, Wu Qiulin, Lin Shuangjun, Li Xiangmei, Liang Jingdan, Zhou Xiufen, An Derong, Deng Zixin, Wang Zhijun
Abstract excerpt
The five-membered aromatic nitrogen heterocyclic pyrrole ring is a building block for a wide variety of natural products. Aiming at generating new pyrrole-containing derivatives as well as to identify new candidates that may be of value in designing new anticancer, antiviral, and/or antimicrobial agents, we employed a strategy on pyrrole-containing compound mutasynthesis using the pyrrole-containing calcimycin...
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