Article
In vitro characterization of echinomycin biosynthesis: formation and hydroxylation of L-tryptophanyl-S-enzyme and oxidation of (2S,3S) β-hydroxytryptophan.
PloS one - 1 Jan 2013
Zhang Chen, Kong Lingxin, Liu Qian, Lei Xuan, Zhu Tao, Yin Jun, Lin Birun, Deng Zixin, You Delin
Abstract excerpt
Quinoxaline-2-carboxylic acid (QXC) and 3-hydroxyquinaldic acid (HQA) feature in quinomycin family and confer anticancer activity. In light of the significant potency against cancer, the biosynthetic gene clusters have been reported from many different Streptomyces strains, and the biosynthetic pathway were proposed mainly based on the in vivo feeding experiment with isotope labeled putative intermediates. Herein...
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