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Dithiolopyrrolone Natural Products: Isolation, Synthesis and Biosynthesis

17 Oct 2013

Abstract excerpt

Dithiolopyrrolones are a class of antibiotics that possess the unique pyrrolinonodithiole (4H-[1,2] dithiolo [4,3-b] pyrrol-5-one) skeleton linked to two variable acyl groups. To date, there are approximately 30 naturally occurring dithiolopyrrolone compounds, including holomycin, thiolutin, and aureothricin, and more recently thiomarinols, a unique class of hybrid marine bacterial natural products containing a...

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PMID: 24141227
DOI: 10.3390/md11103970

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