Article

Maramycin, a cytotoxic isoquinolinequinone terpenoid produced through heterologous expression of a bifunctional indole prenyltransferase /tryptophan indole-lyase in <i>S. albidoflavus</i>

2024-02-14

Abstract excerpt

Isoquinolinequinones represent an important family of natural alkaloids with profound biological activities. Heterologous expression of a rare bifunctional indole prenyltransferase /tryptophan indole-lyase enzyme from Streptomyces mirabilis P8-A2 in S. albidoflavus J1074 led to the activation of a putative isoquinolinequinone biosynthetic gene cluster and production of a novel isoquinolinequinone alkaloid, named...

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Literature Corpus work: 239644e7-6c88-5159-ac1c-2563fc148cb6
DOI: 10.1101/2024.02.14.580309

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Maramycin, a cytotoxic isoquinolinequinone terpenoid produced through heterologous expression of a bifunctional indole prenyltransferase /tryptophan indole-lyase in <i>S. albidoflavus</i>DOI 10.1101/2024.02.14.580309Read

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