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Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic

7 Mar 2009

Abstract excerpt

Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating compounds with significant antitumor properties. Among the pyrrolo[1,4]benzodiazepines (PBDs) sibiromycin, one of two identified glycosylated PBDs, displays the highest affinity for DNA and the most potent antitumor properties. Despite the promising antitumor properties clinical trials of...

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PMID: 19270142
DOI: 10.1128/aem.02326-08

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