Article
p-Aminophenylalanine Involved in the Biosynthesis of Antitumor Dnacin B1 for Quinone Moiety Formation.
Molecules (Basel, Switzerland) - 12 Sept 2020
Hu Xiaojing, Li Xing, Sheng Yong, Wang Hengyu, Li Xiaobin, Ou Yixin, Deng Zixin, Bai Linquan, Kang Qianjin
Abstract excerpt
Actinosynnema species produce diverse natural products with important biological activities, which represent an important resource of antibiotic discovery. Advances in genome sequencing and bioinformatics tools have accelerated the exploration of the biosynthetic gene clusters (BGCs) encoding natural products. Herein, the completed BGCs of dnacin B1 were first discovered in two Actinosynnema pretiosum subsp....
Topics
- Actinobacteria
- Anti-Bacterial Agents
- Antineoplastic Agents
- Biosynthetic Pathways
- Computational Biology
- Drug Screening Assays, Antitumor
- Escherichia coli
- Escherichia coli Proteins
- Fermentation
- Genome, Bacterial