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Article

Associations between HLA-II variation and antibody specificity are predicted by antigen properties.

Genome medicine - 2 Jun 2025

Innocenti Gabriel, Andreu-Sánchez Sergio, Hörstke Nicolai V, Elabd Hesham, Barozzi Iros, Franke Andre, Manczinger Máté, Vogl Thomas

Abstract excerpt

BACKGROUND: Human leukocyte antigen class II (HLA-II) genes are highly polymorphic affecting the specificity of human antibody responses, as presentation of processed antigen peptides by HLA-II on B cells is essential for T helper cell dependent affinity maturation and class switching. The combination of high-throughput immunoassays and genome-wide association studies has recently revealed strong associations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40457459
DOI: 10.1186/s13073-025-01486-w
PMCID: PMC12131526

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