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Article

Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses.

Nature immunology - 1 Mar 2026

Olin Axel, Pou Christian, Jaquaniello Anthony, Crook Jack, Tan Ziyang, Roux Maguelonne, Dubois Florian, Charbit Bruno, Liu Dang, Donnadieu Françoise, Garcia Laura, Lambert Camille, Bloch Emma, Clave Emmanuel, Araujo Itauá Leston, Toubert Antoine, Rotival Maxime, Simon-Lorière Etienne, White Michael, Brodin Petter, Duffy Darragh, Quintana-Murci Lluis, Patin Etienne

Abstract excerpt

Antibodies are central to immune defenses. Despite advances in understanding the mechanisms of antibody generation, a comprehensive model of how intrinsic and external factors shape human humoral responses to viruses has been lacking. Here we apply phage immunoprecipitation sequencing to investigate the effects of demographic factors-including 108 lifestyle and health-related variables-and genetic variation on...

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Aged
Antibodies, Viral
Antibody Specificity
Epitopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Immunity, Humoral

Source

Open in PubMed Open full text

Identifiers

PMID: 41699059
DOI: 10.1038/s41590-026-02432-7
PMCID: PMC12956577

Genes

FUT2
IGH
IGK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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