Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.

Scientific reports - 12 Oct 2015

Godlewski Grzegorz, Jourdan Tony, Szanda Gergő, Tam Joseph, Cinar Resat, Harvey-White Judith, Liu Jie, Mukhopadhyay Bani, Pacher Pál, Ming Mo Fong, Osei-Hyiaman Douglas, Kunos George

Abstract excerpt

We report an unexpected link between aging, thermogenesis and weight gain via the orphan G protein-coupled receptor GPR3. Mice lacking GPR3 and maintained on normal chow had similar body weights during their first 5 months of life, but gained considerably more weight thereafter and displayed reduced total energy expenditure and lower core body temperature. By the age of 5 months GPR3 KO mice already had lower...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue, Brown
Share to Body Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cold Temperature

Share to Ion Channels

Share to Receptors, G-Protein-Coupled

Share to Thermogenesis

Share to Uncoupling Protein 1

Share to Weight Gain

Source

Open in PubMed Open full text

Identifiers

PMID: 26455425
DOI: 10.1038/srep14953
PMCID: PMC4601089

Genes

GPR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.PMID 26455425Read ↗

GPR84-Mediated Signal Transduction Promotes Brown Adipocyte FunctionSemantic proximity Read ↗

Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor.Semantic proximity Read ↗

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.Semantic proximity Read ↗

Central regulation of feeding and body weight by ciliary GPR75Semantic proximity Read ↗

Night eating and obesity in the EP3R-deficient mouse.Semantic proximity Read ↗

Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39.Semantic proximity Read ↗

Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice.Semantic proximity Read ↗

GPR39, a receptor of the ghrelin receptor family, plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity.Semantic proximity Read ↗

GPR10 deficiency in mice results in altered energy expenditure and obesity.Semantic proximity Read ↗

Impaired Glucose Metabolism in Mice Lacking the Tas1r3 Taste Receptor Gene.Semantic proximity Read ↗

Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82.Semantic proximity Read ↗

Brown adipose tissue specific lack of uncoupling protein 3 is associated with impaired cold tolerance and reduced transcript levels of metabolic genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.