Article
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Cell - 24 Jun 2021
Sveidahl Johansen Olivia, Ma Tao, Hansen Jakob Bondo, Markussen Lasse Kruse, Schreiber Renate, Reverte-Salisa Laia, Dong Hua, Christensen Dan Ploug, Sun Wenfei, Gnad Thorsten, Karavaeva Iuliia, Nielsen Thomas Svava, Kooijman Sander, Cero Cheryl, Dmytriyeva Oksana, Shen Yachen, Razzoli Maria, O'Brien Shannon L, Kuipers Eline N, Nielsen Carsten Haagen, Orchard William, Willemsen Nienke, Jespersen Naja Zenius, Lundh Morten, Sustarsic Elahu Gosney, Hallgren Cecilie Mørch, Frost Mikkel, McGonigle Seth, Isidor Marie Sophie, Broholm Christa, Pedersen Oluf, Hansen Jacob Bo, Grarup Niels, Hansen Torben, Kjær Andreas, Granneman James G, Babu M Madan, Calebiro Davide, Nielsen Søren, Rydén Mikael, Soccio Raymond, Rensen Patrick C N, Treebak Jonas Thue, Schwartz Thue Walter, Emanuelli Brice, Bartolomucci Alessandro, Pfeifer Alexander, Zechner Rudolf, Scheele Camilla, Mandrup Susanne, Gerhart-Hines Zachary
Abstract excerpt
Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GPCR-mediated adipose thermogenesis through the constitutively active receptor, GPR3. We show that the N terminus of GPR3 confers intrinsic signaling activity, resulting...
Read the complete abstract on PubMed