Article
Night eating and obesity in the EP3R-deficient mouse.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007
Sanchez-Alavez Manuel, Klein Izabella, Brownell Sara E, Tabarean Iustin V, Davis Christopher N, Conti Bruno, Bartfai Tamas
Abstract excerpt
Adult mice carrying a null mutation of the prostanoid receptor EP3R (EP3R(-/-) mice) exhibit increased frequency of feeding during the light cycle of the day and develop an obese phenotype under a normal fat diet fed ad libitum. EP3R(-/-) mice show increased motor activity, which is not sufficient to offset the increased feeding leading to increased body weight. Altered "nocturnal" activity and feeding behavior...
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