Article
EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.
Molecular cell - 15 Oct 2015
Liu Feng, Hon Gary C, Villa Genaro R, Turner Kristen M, Ikegami Shiro, Yang Huijun, Ye Zhen, Li Bin, Kuan Samantha, Lee Ah Young, Zanca Ciro, Wei Bowen, Lucey Greg, Jenkins David, Zhang Wei, Barr Cathy L, Furnari Frank B, Cloughesy Timothy F, Yong William H, Gahman Timothy C, Shiau Andrew K, Cavenee Webster K, Ren Bing, Mischel Paul S
Abstract excerpt
Epidermal growth factor receptor (EGFR) gene amplification and mutations are the most common oncogenic events in glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses of cell lines, genotyped clinical samples, and TCGA data, we show that EGFR mutations remodel the activated enhancer landscape of...
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