Article
Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype.
Nature communications - 18 Dec 2020
Wu Yonghe, Fletcher Michael, Gu Zuguang, Wang Qi, Costa Barbara, Bertoni Anna, Man Ka-Hou, Schlotter Magdalena, Felsberg Jörg, Mangei Jasmin, Barbus Martje, Gaupel Ann-Christin, Wang Wei, Weiss Tobias, Eils Roland, Weller Michael, Liu Haikun, Reifenberger Guido, Korshunov Andrey, Angel Peter, Lichter Peter, Herrmann Carl, Radlwimmer Bernhard
Abstract excerpt
Glioblastoma frequently exhibits therapy-associated subtype transitions to mesenchymal phenotypes with adverse prognosis. Here, we perform multi-omic profiling of 60 glioblastoma primary tumours and use orthogonal analysis of chromatin and RNA-derived gene regulatory networks to identify 38 subtype master regulators, whose cell population-specific activities we further map in published single-cell RNA sequencing...
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