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Epigenetic regulation of histone modifications in glioblastoma: recent advances and therapeutic insights

31 May 2025

Abstract excerpt

Glioblastoma (GBM) is the most common primary malignant brain tumor, characterized by its aggressive behavior, limited treatment options, and poor prognosis. Despite advances in surgery, radiotherapy, and chemotherapy, the median survival of GBM patients remains disappointingly short. Recent studies have underscored the critical role of histone modifications in GBM malignant progression and therapy resistance....

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Share to Epigenetics and DNA Methylation
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Share to Histone Deacetylase Inhibitors Research

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PMID: 40450300
DOI: 10.1186/s40364-025-00788-w

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