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Article

BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs).

Journal of molecular and cellular cardiology - 1 Dec 2015

Agsten Marianne, Hessler Sabine, Lehnert Sandra, Volk Tilmann, Rittger Andrea, Hartmann Stephanie, Raab Christian, Kim Doo Yeon, Groemer Teja W, Schwake Michael, Alzheimer Christian, Huth Tobias

Abstract excerpt

KCNQ1 (Kv7.1) proteins form a homotetrameric channel, which produces a voltage-dependent K(+) current. Co-assembly of KCNQ1 with the auxiliary β-subunit KCNE1 strongly up-regulates this current. In cardiac myocytes, KCNQ1/E1 complexes are thought to give rise to the delayed rectifier current IKs, which contributes to cardiac action potential repolarization. We report here that the type I membrane protein BACE1...

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Source

Identifiers

PMID: 26454161
DOI: 10.1016/j.yjmcc.2015.10.006

Genes

BACE1
KCNQ1
APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs).PMID 26454161Read ↗

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