Article

Recruitment of Neuronal KCNQ2/3 Channels to Membrane Microdomains by Palmitoylation of Alzheimer’s Disease-Related Protein BACE1

2020-10-01

Abstract excerpt

<h4>ABSTRACT</h4> β-secretase 1 (β-site amyloid precursor protein (APP)-cleaving enzyme 1, BACE1) plays a crucial role in the amyloidogenesis of Alzheimer’s Disease (AD). BACE1 was also discovered to act like an auxiliary subunit to modulate neuronal KCNQ2/3 channels independent of its proteolytic function. BACE1 is palmitoylated at its carboxyl-terminal region, which brings BACE1 to ordered, cholesterol-rich mem...

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Literature Corpus work: 9ccee489-0367-50da-9f94-ab1111af18e1
DOI: 10.1101/2020.09.30.321307

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