Mutation E87Q of the β1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel.

doi:10.1038/s41598-017-10645-y

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Article

Mutation E87Q of the β1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel.

Scientific reports - 6 Sept 2017

Baroni Debora, Picco Cristiana, Moran Oscar

Abstract excerpt

Voltage-dependent sodium channels are responsible of the rising phase of the action potential in excitable cells. These membrane integral proteins are composed by a pore-forming α-subunit, and one or more auxiliary β subunits. Mutation E87Q of the β1 subunit is correlated with Brugada syndrome, a...

Topics

Alleles
Amino Acid Substitution
Animals
CHO Cells
Cricetulus
Fluorescent Antibody Technique
Gene Expression
Humans
Multigene Family
Mutation
Voltage-Gated Sodium Channel beta-1 Subunit

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