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Article

Mutation E87Q of the β1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel.

Scientific reports - 6 Sept 2017

Baroni Debora, Picco Cristiana, Moran Oscar

Abstract excerpt

Voltage-dependent sodium channels are responsible of the rising phase of the action potential in excitable cells. These membrane integral proteins are composed by a pore-forming α-subunit, and one or more auxiliary β subunits. Mutation E87Q of the β1 subunit is correlated with Brugada syndrome, a genetic disease characterised by ventricular fibrillation, right precordial ST segment elevation on ECG and sudden...

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Identifiers

PMID: 28878239
DOI: 10.1038/s41598-017-10645-y
PMCID: PMC5587543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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