Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of cystathionine beta synthase in lipid metabolism in ovarian cancer.

Oncotarget - 10 Nov 2015

Chakraborty Prabir K, Xiong Xunhao, Mustafi Soumyajit Banerjee, Saha Sounik, Dhanasekaran Danny, Mandal Nawajes A, McMeekin Scott, Bhattacharya Resham, Mukherjee Priyabrata

Abstract excerpt

Elevated lipid metabolism is implicated in poor survival in ovarian cancer (OC) and other cancers; however, current lipogenesis-targeting strategies lack cancer cell specificity. Here, we identify a novel role of cystathionine beta-synthase (CBS), a sulphur amino acid metabolizing enzyme highly expressed in several ovarian cancer cell lines, in driving deregulated lipid metabolism in OC. We examined the role of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystathionine beta-Synthase
Share to Heterografts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipogenesis

Share to Mice, Nude

Share to Neovascularization, Physiologic

Share to Sp1 Transcription Factor

Share to Sterol Regulatory Element Binding Protein 1

Share to Sterol Regulatory Element Binding Protein 2

Source

Open in PubMed Open full text

Identifiers

PMID: 26452259
DOI: 10.18632/oncotarget.5424
PMCID: PMC4741935

Genes

CBS
FASN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of cystathionine beta synthase in lipid metabolism in ovarian cancer.PMID 26452259Read ↗

Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance.Semantic proximity Read ↗

Cystathionine Beta-Synthase Promotes Anoikis Resistance and Transcoelomic Metastasis in Ovarian Cancer via SP1- ITGB1 regulationSemantic proximity Read ↗

Sterol regulatory element-binding protein 1 is required for ovarian tumor growthSemantic proximity Read ↗

Suppression of the ABCA1 Cholesterol Transporter Impairs the Growth and Migration of Epithelial Ovarian CancerSemantic proximity Read ↗

Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical modelsSemantic proximity Read ↗

Lysophosphatidic Acid Activates Lipogenic Pathways and de Novo Lipid Synthesis in Ovarian Cancer CellsSemantic proximity Read ↗

Cystathionineβ-Synthase in Physiology and CancerSemantic proximity Read ↗

Activation of the apolipoprotein A1-SRB1 pathway increases vascular permeability in ovaries with lipotoxicitySemantic proximity Read ↗

Dysregulated Cholesterol Metabolism with Anomalous PI3K/Akt/mTOR pathway Predicts Poor Carboplatin Response in High Grade Serous Ovarian CancerSemantic proximity Read ↗

SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway.Semantic proximity Read ↗

Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor GrowthSemantic proximity Read ↗

Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARCSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.