Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lysophosphatidic Acid Activates Lipogenic Pathways and de Novo Lipid Synthesis in Ovarian Cancer Cells

5 Jun 2012

Abstract excerpt

One of the most common molecular changes in cancer is the increased endogenous lipid synthesis, mediated primarily by overexpression and/or hyperactivity of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC). The changes in these key lipogenic enzymes are critical for the development and maintenance of the malignant phenotype. Previous efforts to control oncogenic lipogenesis have been focused on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Cholesterol and Lipid Metabolism
Share to Lipid metabolism and biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22665482
DOI: 10.1074/jbc.m112.340083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lysophosphatidic Acid Activates Lipogenic Pathways and de Novo Lipid Synthesis in Ovarian Cancer CellsPMID 22665482Read ↗

Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells.Semantic proximity Read ↗

Cell type‐selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironmentSemantic proximity Read ↗

Lysophosphatidic acid receptors in cancer pathobiology.Semantic proximity Read ↗

LPA3 Is a Precise Therapeutic Target And Potential Biomarker For Ovarian CancerSemantic proximity Read ↗

Role of cystathionine beta synthase in lipid metabolism in ovarian cancer.Semantic proximity Read ↗

PLA2G2A Phospholipase Promotes Fatty Acid Synthesis and Energy Metabolism in Pancreatic Cancer Cells with K-ras Mutation.Semantic proximity Read ↗

Sterol regulatory element-binding protein 1 is required for ovarian tumor growthSemantic proximity Read ↗

Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progressionSemantic proximity Read ↗

Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.Semantic proximity Read ↗

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.Semantic proximity Read ↗

Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis.Semantic proximity Read ↗

New links between lipid accumulation and cancer progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.