Article
Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance.
PloS one - 1 Jan 2013
Bhattacharyya Sanjib, Saha Sounik, Giri Karuna, Lanza Ian R, Nair K Sreekumar, Jennings Nicholas B, Rodriguez-Aguayo Cristian, Lopez-Berestein Gabriel, Basal Eati, Weaver Amy L, Visscher Daniel W, Cliby William, Sood Anil K, Bhattacharya Resham, Mukherjee Priyabrata
Abstract excerpt
BACKGROUND: Epithelial ovarian cancer is the leading cause of gynecologic cancer deaths. Most patients respond initially to platinum-based chemotherapy after surgical debulking, however relapse is very common and ultimately platinum resistance emerges. Understanding the mechanism of tumor growth, metastasis and drug resistant relapse will profoundly impact the therapeutic management of ovarian cancer....
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