Article

Cystathionine Beta-Synthase Promotes Anoikis Resistance and Transcoelomic Metastasis in Ovarian Cancer via SP1- ITGB1 regulation

2025-12-15

Abstract excerpt

Anoikis resistance is crucial for ovarian cancer (OvCa) transcoelomic metastasis, during which exfoliated OvCa cells survive as spheroids before invading the omentum. Here, we demonstrate that cystathionine β-synthase (CBS), an H 2 S-producing transsulfuration pathway enzyme, is a key determinant of OvCa spheroidal viability and metastatic potential. Analysis of publicly available patient datasets, as well as an...

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Literature Corpus work: a52cf096-9e1a-5913-9f31-251cd8877fd6
DOI: 10.64898/2025.12.12.694000

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