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Article

SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway.

Endocrine-related cancer - 13 Dec 2021

Kuo Chi-Yu, Chang Yuan-Ching, Chien Ming-Nan, Jhuang Jie-Yang, Hsu Yi-Chiung, Huang Shih-Yuan, Cheng Shih-Ping

Abstract excerpt

Aberrant lipid metabolism provides bioenergetic, biosynthetic, and redox supplies to cancer cells. Previous studies have reported differential lipid profiling in thyroid malignancies. Sterol regulatory element-binding protein 1 (SREBP1), encoded by the SREBF1 gene, is a master regulator of cellular lipid homeostasis. The clinical and functional significance of SREBP1 in thyroid cancer is not well understood....

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Source

Identifiers

PMID: 34821220
DOI: 10.1530/ERC-21-0256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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