Article

Activation of the apolipoprotein A1-SRB1 pathway increases vascular permeability in ovaries with lipotoxicity

2025-11-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Excessive cholesterol causes lipid accumulation and plaque buildup in blood vessels, reducing blood supply and ovarian function. The apolipoprotein A1 (ApoA1)-scavenger receptor class B member 1 (SRB1) signaling is crucial in lipid-induced vascular permeability and ovarian steroidogenesis. We previously reported that placenta-derived mesenchymal stem cells (PD-MSCs) improve o...

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Literature Corpus work: 59186fb7-657e-56b2-9f27-b91988c335e4
DOI: 10.1101/2025.11.04.25339539

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