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Cystathionineβ-Synthase in Physiology and Cancer

28 Jun 2018

Abstract excerpt

Cystathionineβ-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification. Inactivating mutations in CBS contribute to the pathogenesis of the autosomal recessive disease CBS-deficient homocystinuria. Recent studies...

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PMID: 30050925
DOI: 10.1155/2018/3205125

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