Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor Growth

Abstract excerpt

<h4>ABSTRACT</h4> Loss of tumor suppressor gene (TSG) activity is pervasive across cancers and linked to worse clinical outcomes, yet therapeutic efforts aimed at restoring TSGs have remained elusive. One underexplored avenue to address this problem is the targeting of metabolic signaling pathways that actively enforce tumor suppressive programs. Ceramide (Cer), the central hub of the sphingolipid (SL) metabolic...

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• Autophagy in Disease and Therapy
• Cholesterol and Lipid Metabolism
• Drug Transport and Resistance Mechanisms
• Endoplasmic Reticulum Stress and Disease
• Erythrocyte Function and Pathophysiology
• Lipid Membrane Structure and Behavior
• Phagocytosis and Immune Regulation
• Sphingolipid Metabolism and Signaling

Identifiers and source

Literature Corpus work

c5e9afb0-bc9b-5179-a0d1-0a59f84d7626

DOI

10.64898/2026.05.13.724348