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Article

PERK: a novel therapeutic target for neurodegenerative diseases?

29 May 2014

Abstract excerpt

Identification of therapeutic targets based on novel mechanistic studies is urgently needed for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and prion disease. Multiple lines of evidence have emerged to suggest that inhibition of the stress-induced endoplasmic reticulum kinase PERK (protein kinase RNA-like endoplasmic reticulum kinase) is a potential therapeutic strategy for these...

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Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Genetics and Neurodevelopmental Disorders

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Identifiers

PMID: 25031640
DOI: 10.1186/alzrt260

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Related research

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PERK: a novel therapeutic target for neurodegenerative diseases?PMID 25031640Read ↗

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Fine‐tuning PERK signaling for neuroprotectionSemantic proximity Read ↗

Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.Semantic proximity Read ↗

The Potential Role of Protein Kinase R as a Regulator of Age-Related NeurodegenerationSemantic proximity Read ↗

Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation.Semantic proximity Read ↗

Neurodegeneration Risk Factor, <i>EIF2AK3</i> ( <i>PERK</i> ), Influences Tau Protein AggregationSemantic proximity Read ↗

Therapeutic Effects of Natural Compounds and Small Molecule Inhibitors Targeting Endoplasmic Reticulum Stress in Alzheimer’s DiseaseSemantic proximity Read ↗

PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum StressSemantic proximity Read ↗

The role of endoplasmic reticulum stress in neurodegenerative diseaseSemantic proximity Read ↗

Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulumSemantic proximity Read ↗

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