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Article

Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation.

The Journal of biological chemistry - 1 Feb 2023

Park Goonho, Xu Ke, Chea Leon, Kim Kyle, Safarta Lance, Song Keon-Hyoung, Wu Jian, Park Soyoung, Min Hyejung, Hiramatsu Nobuhiko, Han Jaeseok, Lin Jonathan H

Abstract excerpt

Tauopathies are neurodegenerative diseases caused by pathologic misfolded tau protein aggregation in the nervous system. Population studies implicate EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3), better known as PERK (protein kinase R-like endoplasmic reticulum kinase), as a genetic risk factor in several tauopathies. PERK is a key regulator of intracellular proteostatic mechanisms-unfolded...

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Identifiers

PMID: 36563857
DOI: 10.1016/j.jbc.2022.102821
PMCID: PMC9852698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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