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Article

Alzheimer’s disease-related dysregulation of mRNA translation causes key pathological features with ageing

16 Jun 2020

Abstract excerpt

Alzheimer's disease (AD) is characterised by Aβ and tau pathology as well as synaptic degeneration, which correlates best with cognitive impairment. Previous work suggested that this pathological complexity may result from changes in mRNA translation. Here, we studied whether mRNA translation and its underlying signalling are altered in an early model of AD, and whether modelling this deficiency in mice causes...

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PMID: 32546772
DOI: 10.1038/s41398-020-00882-7

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