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Article

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2015

Simon Michelle M, Moresco Eva Marie Y, Bull Katherine R, Kumar Saumya, Mallon Ann-Marie, Beutler Bruce, Potter Paul K

Abstract excerpt

Mutagenesis-based screens in mice are a powerful discovery platform to identify novel genes or gene functions associated with disease phenotypes. An N-ethyl-N-nitrosourea (ENU) mutagenesis screen induces single nucleotide variants randomly in the mouse genome. Subsequent phenotyping of mutant and wildtype mice enables the identification of mutated pathways resulting in phenotypes associated with a particular ENU...

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Identifiers

PMID: 26449678
DOI: 10.1007/s00335-015-9603-x
PMCID: PMC4602060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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