Variant mapping and mutation discovery in inbred mice using next-generation sequencing.

Abstract excerpt

BACKGROUND: The development of powerful new methods for DNA sequencing enable the discovery of sequence variants, their utilization for the mapping of mutant loci, and the identification of causal variants in a single step. We have applied this approach for the analysis of ENU-mutagenized mice maintained on an inbred background. RESULTS: We ascertained ENU-induced variants in four different phenotypically mutant...

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