Article
Spectrum of ENU-induced mutations in phenotype-driven and gene-driven screens in the mouse.
Environmental and molecular mutagenesis - 1 Mar 2007
Barbaric Ivana, Wells Sara, Russ Andreas, Dear T Neil
Abstract excerpt
N-ethyl-N-nitrosourea (ENU) mutagenesis in mice has become a standard tool for (i) increasing the pool of mutants in many areas of biology, (ii) identifying novel genes involved in physiological processes and disease, and (iii) in assisting in assigning functions to genes. ENU is assumed to cause random mutations throughout the mouse genome, but this presumption has never been analyzed. This is a crucial point,...
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