Article
Using ENU mutagenesis for phenotype-driven analysis of the mouse.
Methods in enzymology - 1 Jan 2010
Stottmann Rolf W, Beier David R
Abstract excerpt
The use of mutagenesis in invertebrates to generate phenotypic variants has a long and productive history. Despite the conclusive demonstration by Russell and colleagues in the 1970s that the chemical N-ethyl-N-nitrosourea (ENU) is a highly effective mutagen in mice, the application of phenotypic-driven mutagenesis as a method to study mammalian biology proceeded slowly. With the development of tools for genomic...
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