Using ENU mutagenesis for phenotype-driven analysis of the mouse.

doi:10.1016/S0076-6879(10)77017-8

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Article

Using ENU mutagenesis for phenotype-driven analysis of the mouse.

Methods in enzymology - 1 Jan 2010

Stottmann Rolf W, Beier David R

Abstract excerpt

The use of mutagenesis in invertebrates to generate phenotypic variants has a long and productive history. Despite the conclusive demonstration by Russell and colleagues in the 1970s that the chemical N-ethyl-N-nitrosourea (ENU) is a highly effective mutagen in mice, the application of phenotypic-driven mutagenesis as a method to study mammalian biology proceeded slowly. With the development of tools for genomic...

Topics

Animals
Ethylnitrosourea
Mice
Mutagenesis
Mutagens
Phenotype

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Open in PubMed

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PMID: 20699149
DOI: 10.1016/S0076-6879(10)77017-8

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