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Article

SNP-derived CpG variation and DNA methylation linking genetic susceptibility to metabolic disease.

Epigenomics - 1 Aug 2026

Khanna Kamakshi, Alam Sana

Abstract excerpt

DNA methylation at CpG dinucleotides represents a key epigenetic mechanism linking genetic variation to gene regulation in complex human diseases. Single-nucleotide polymorphisms (SNPs) that create or disrupt CpG sites can alter local DNA methylation and transcriptional activity, thereby influencing disease susceptibility. These CpG-modifying variants provide a functional interface between inherited genetic...

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Identifiers

PMID: 42473718
DOI: 10.1080/17501911.2026.2705144
PMCID: PMC13540215

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