Article
Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference.
Obesity (Silver Spring, Md.) - 1 Jul 2015
Aslibekyan Stella, Demerath Ellen W, Mendelson Michael, Zhi Degui, Guan Weihua, Liang Liming, Sha Jin, Pankow James S, Liu Chunyu, Irvin Marguerite R, Fornage Myriam, Hidalgo Bertha, Lin Li-An, Thibeault Krista Stanton, Bressler Jan, Tsai Michael Y, Grove Megan L, Hopkins Paul N, Boerwinkle Eric, Borecki Ingrid B, Ordovas Jose M, Levy Daniel, Tiwari Hemant K, Absher Devin M, Arnett Donna K
Abstract excerpt
OBJECTIVE: To conduct an epigenome-wide analysis of DNA methylation and obesity traits. METHODS: DNA methylation was quantified in CD4+ T-cells using the Illumina Infinium HumanMethylation450 array in 991 participants of the Genetics of Lipid Lowering Drugs and Diet Network. Methylation at individual cytosine-phosphate-guanine (CpG) sites as a function of body mass index (BMI) and waist circumference (WC),...
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