Article
Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure.
Hepatology (Baltimore, Md.) - 1 Oct 2009
Rauch Andri, James Ian, Pfafferott Katja, Nolan David, Klenerman Paul, Cheng Wendy, Mollison Lindsay, McCaughan Geoff, Shackel Nick, Jeffrey Gary P, Baker Ross, Freitas Elizabeth, Humphreys Isla, Furrer Hansjakob, Günthard Huldrych F, Hirschel Bernard, Mallal Simon, John Mina, Lucas Michaela, Barnes Eleanor, Gaudieri Silvana
Abstract excerpt
UNLABELLED: Many hepatitis C virus (HCV) infections worldwide are with the genotype 1 and 3 strains of the virus. Cellular immune responses are known to be important in the containment of HCV genotype 1 infection, and many genotype 1 T cell targets (epitopes) that are presented by host human leukocyte antigens (HLAs) have been identified. In contrast, there is almost no information known about the equivalent...
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