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Article

APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration

7 Oct 2015

Abstract excerpt

Contrary to Alzheimer's disease (AD), the APOE2 allele increases and the APOE4 allele reduces the risk to develop age-related macular degeneration (AMD) compared with the most common APOE3 allele. The underlying mechanism for this association with AMD and the reason for the puzzling difference with AD are unknown. We previously demonstrated that pathogenic subretinal mononuclear phagocytes (MPs) accumulate in...

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PMID: 26446211
DOI: 10.1523/jneurosci.2468-15.2015

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