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Article

An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation.

Environmental and molecular mutagenesis - 1 Oct 2006

Bojanowski Christine M, Shen Defen, Chew Emily Y, Ning Baitang, Csaky Karl G, Green W Richard, Chan Chi-Chao, Tuo Jingsheng

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness among the elderly in Western countries. Genetic factors, age, cigarette smoking, nutrition, and exposure to light have been identified as AMD risk factors. In this study, we investigated the association between ApoE C112R/R158C single nucleotide polymorphisms (which determine the E2, E3, and E4 isoforms) and age-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 16823865
DOI: 10.1002/em.20233
PMCID: PMC1899525

Genes

CCL2
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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