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Article

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

The Journal of clinical investigation - 1 Oct 2007

Combadière Christophe, Feumi Charles, Raoul William, Keller Nicole, Rodéro Mathieu, Pézard Adeline, Lavalette Sophie, Houssier Marianne, Jonet Laurent, Picard Emilie, Debré Patrice, Sirinyan Mirna, Deterre Philippe, Ferroukhi Tania, Cohen Salomon-Yves, Chauvaud Dominique, Jeanny Jean-Claude, Chemtob Sylvain, Behar-Cohen Francine, Sennlaub Florian

Abstract excerpt

The role of retinal microglial cells (MCs) in age-related macular degeneration (AMD) is unclear. Here we demonstrated that all retinal MCs express CX3C chemokine receptor 1 (CX3CR1) and that homozygosity for the CX3CR1 M280 allele, which is associated with impaired cell migration, increases the r...

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Identifiers

PMID: 17909628
DOI: 10.1172/JCI31692
PMCID: PMC1994614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17909628-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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