Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration

Abstract excerpt

Introduction Age-related macular degeneration (AMD) is a leading cause of blindness with limited treatment options. Dysfunction of the retinal pigment epithelium (RPE) is a unifying salient feature of the pathology and a primary end-point damage leading to complications such as geographic atrophy (GA), which represents the most common end-stage of AMD. Methods Human and murine ocular tissues were used for...

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