Article
MAPT H1 Haplotype is Associated with Late-Onset Alzheimer's Disease Risk in APOEɛ4 Noncarriers: Results from the Dementia Genetics Spanish Consortium.
Journal of Alzheimer's disease : JAD - 1 Jan 2016
Pastor Pau, Moreno Fermín, Clarimón Jordi, Ruiz Agustín, Combarros Onofre, Calero Miguel, López de Munain Adolfo, Bullido Maria J, de Pancorbo Marian M, Carro Eva, Antonell Anna, Coto Eliecer, Ortega-Cubero Sara, Hernandez Isabel, Tárraga Lluís, Boada Mercè, Lleó Alberto, Dols-Icardo Oriol, Kulisevsky Jaime, Vázquez-Higuera José Luis, Infante Jon, Rábano Alberto, Fernández-Blázquez Miguel Ángel, Valentí Meritxell, Indakoetxea Begoña, Barandiarán Myriam, Gorostidi Ana, Frank-García Ana, Sastre Isabel, Lorenzo Elena, Pastor María A, Elcoroaristizabal Xabier, Lennarz Martina, Maier Wolfang, Rámirez Alfredo, Serrano-Ríos Manuel, Lee Suzee E, Sánchez-Juan Pascual
Abstract excerpt
The MAPT H1 haplotype has been linked to several disorders, but its relationship with Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p.A152T) has been linked with frontotemporal dementia (FTD) and AD. We genotyped H1/H2 and p.A152T MAPT in 11,572 subjects from Spain (4,327 AD, 563 FTD, 648 Parkinson's disease (PD), 84 progressive supranuclear palsy (PSP), and 5,950 healthy controls)....
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