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Article

MAPT Haplotype Variation and Alzheimer's Disease Risk: A Narrative Review with Focus on the Jordanian Population.

Current neuropharmacology - 1 Jan 2026

Aljabali Alaa A A, Alkaraki Almuthanna K, Obeid Mohammad A

Abstract excerpt

INTRODUCTION: Genetic variations in the microtubule-associated protein tau (MAPT) gene play a central role in Alzheimer's disease (AD) pathogenesis. Two major MAPT haplotypes, H1 and H2, show differential associations with tau expression and AD risk. However, data from Middle Eastern populations remain limited, restricting our understanding of population-specific disease susceptibility patterns and therapeutic...

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Alzheimer Disease
APOE gene
MAPT gene
Genetic Predisposition to Disease
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40947724
DOI: 10.2174/011570159X371971250818110608
PMCID: PMC13523329

Genes

MAPT
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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