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Article

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

14 Apr 2016

Abstract excerpt

Disrupting mutations of the RUNX1 gene are found in 10% of patients with myelodysplasia (MDS) and 30% of patients with acute myeloid leukemia (AML). Previous studies have revealed an increase in hematopoietic stem cells (HSCs) and multipotent progenitor (MPP) cells in conditional Runx1-knockout (KO) mice, but the molecular mechanism is unresolved. We investigated the myeloid progenitor (MP) compartment in KO...

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Identifiers

PMID: 27076172
DOI: 10.1182/blood-2015-09-668129

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